The goal of this special issue is to collect high quality papers containing results in computer science applications for health care and medical environments. In particular, we invite papers on solutions and prototypes that already have found their utilization in clinical houses or in biomedical laboratories, both in patient front solutions (such as surgery room, electronic patient records improvements, medical doctor decision process) or in back office solutions (such as in biological laboratory, off line clinical data analysis). TOPICS OF INTEREST Research areas of relevance to this special issue would therefore include, but are not limited to, the following topics: - advanced solutions for clinical information system - bioinformatics applications for genomics and proteomics - bioinformatics applications for medical images - medical data and communication integration - high performance computation within health care applications - Peer-to-Peer and large scale social networks techniques for health care problems managements (e.g., epidemiological control and studies) - data management and communication improvements in large scale health care systems - large-scale Electronic Health Records - high-performance simulations of organs - high-performance simulations of biological systems - large-scale, trans-national health-care infrastructures and applications The special issue is also interested in computer science solutions integrated in electronic devices, or high performance communication solutions supporting health care management problems, as for instance: - telemedicine, - integrated Informatics Systems for Medicine, - high performance and portable clinical data management solutions. IMPORTANT DATES: Paper submission: 30 September, 2010 First Decision notification: 15 December, 2010 Revised Paper Submission: 31 January, 2011 Second Decision notification: 31 March, 2011 Final papers: 30 April, 2011 Tentative Publication Schedule: 2011