A postdoc position for a computational biologist is available in the bioinformatics team "Genome Analysis" (http://www.cgm.cnrs-gif.fr/thermes/index.html) located in the Centre de Génétique Moléculaire in the campus of Gif sur Yvette, near Paris (http://www.cgm.cnrs-gif.fr/version_gb/access_cgm.html).
The main lines of interest of our group are: the role of replication and transcription in genome organization and stability during evolution and in pathologies; the mutational asymmetries associated with transcription and replication; the role of sequence on nucleosome positioning and dynamics and the effect of these mechanisms on gene expression and regulation.
Subject : The postdoc will study the links between the replication organisation of the human genome (position of replication origins, spatio-temporal program of their activation) and the chromosomal anomalies in cancer cells (translocations, amplified fragments, deletions, etc.) using high-throughput data from collaborating groups of biologists (massive sequencing, CGH arrays).
The candidate will have a PhD in bioinformatics; experience with high-throughput data is required.
The position is funded by the CNRS initially for 12 months and is available immediately. Mensual salary: 2088 EUR.

Selected publications of the group
Miele, V., Vaillant, C., d'Aubenton-Carafa, Y., Thermes, C. and Grange, T. (2008) DNA physical properties determine nucleosome occupancy from yeast to fly. Nucleic Acids Res, 36, 3746-3756.
Huvet, M., Nicolay, S., Touchon, M., Audit, B., d'Aubenton-Carafa, Y.,  Arneodo, A. and Thermes, C. (2007) Human gene organization driven by the coordination of replication and transcription. Genome Res., 17, 1278-1285.
Audit, B., Nicolay, S., Huvet, M., Touchon, M., d'Aubenton-Carafa, Y., Thermes, C. and Arneodo, A. (2007) DNA Replication Timing Data Corroborate In Silico Human Replication Origin Predictions. Phys. Rev. Lett., 99, 248102.
Touchon, M., Nicolay, S., Audit, B., Brodie of Brodie, E.B., d'Aubenton-
Carafa, Y., Arneodo, A. and Thermes, C. (2005) Replication-associated strand asymmetries in mammalian genomes: Toward detection of replication origins. Proc. Natl. Acad. Sci. USA, 102, 9836-9841.
Touchon, M., Arneodo, A., d'Aubenton-Carafa, Y. and Thermes, C. (2004) Transcription-coupled and splicing-coupled strand asymmetries in eukaryotic genomes. Nucleic Acids Res., 32, 4969-4978.