Exploring Modular Protein Architecture

EMBL Heidelberg, Germany

Over the last few years a new paradigm has been emerging concerning the nature of Eukaryotic regulatory proteins - contrasting with the nice neat globular protein view expounded by biochemical and cell biological textbooks. Instead, many proteins have a remarkable number of architecture modules - including long natively disordered segments and short linear motifs that are awkward to investigate computationally and experimentally.

The course will set the scene by introducing the biological concepts behind these architecture modules and provide extensive hands-on application of the relevant bioinformatics tools with appropriate example proteins. The power - but also the limitations, which remain substantial - of the currently available software will be examined.

 

Topics:

Introduction to Common Bioinformatic Tools (optional initial half day at no extra cost)
Multiple Sequence Alignment
Protein-Protein Interaction Networks
Predicting Globular Domains and Native Disorder