Course dates: November 8th-10th 2010
Course description:
In the last few years, the study of the genetic basis of cancer has
undergone a profound transformation. High-throughput techniques, such
as microarrays and next generation sequencing technologies, allow
scientists to identify genetic alterations at genome-wide level in
many tumour types. The application of these technologies to the study
of cancer is very powerful to understand the mechanism of disease
pathogenesis, and it has a high potential to identify possible targets
for therapy, discover molecular biomarkers that allow an early
detection of cancer, improve the diagnosis and prognosis or certain
tumours, and predict the response to therapies. The application of
these technologies yields complex, multidimensional genomic data sets
that describe in detail the myriad changes that occur within
individual tumours and how these changes differ between individual
tumours. As a consequence, modern cancer research has become a hybrid
of molecular and bioinformatic methods. The course will provide the
students with theoretical and practical expertise in the field of
integrative cancer genomics. We will introduce the large oncogenomic
projects that are active, such as The Cancer Genome Atlas and the
International Cancer Genome Consortium. And we will learn how to use
tools to access, manipulate and take advantage of the large amount of
available cancer genomics data. Some tools we will use are IntOGen,
Oncomine, COSMIC, ICGC-DCC and MEV, among others.
Target Audience
The course is directed to researchers in biology and medicine.
Background knowledge in bioinformatics is not necessary. Attendees
will be updated on the state of the art in the field of cancer
genomics and they will become capable of handling and analyzing cancer
genomics data. Upon completion, the atendees will be able to perform
integrative analysis and interpret the results, in order to answer
specific biological questions.
More information, including application details at
http://gtpb.igc.gulbenkian.pt/bicourses/ICG10
Information on all GTPB courses at
