You are a talented computational biologist or bioinformatician and you are looking for a postdoctoral project that will give you the opportunity to make a difference in cancer patient care. We offer you a unique opportunity in radiotherapy personalized medicine.
Certain patients suffer long term toxicity side effects (chronic inflammation) after treatment and their identification beforehand remains a challenge. Taking advantage of a large biobank of breast and prostate tumors with full medical records and genetic profiles, we want to unravel the genetic factor(s) of late toxicity in radiotherapy using these two tumors as a model. Quantitative proteomics data are available for a subset of patients. You will use data integration and network biology concepts to identify the responsible mutation(s). Furthermore, we have developed a successful cellular assay able to identify patients not suffering side effects with 99% confidence, which was performed on all patients of the biobank. These data will help in identifying the responsible genetics.
The successful candidate will have a solid background in statistics, computer programming, and bioinformatics. Previous experience with NGS data and knowledge of cancer biology would be a plus. The ability to exchange with biologists and clinicians is essential as the project will take place at the interface of a biomedical (Prof. D. Azria) and a computational (Prof. J. Colinge) group within the IRCM, Montpellier Cancer Research Institute, and ICM, Montpellier Cancer Institute (regional cancer clinic). The project is an essential part the “Radiobiology applied to Oncology” research Program developed through the SIRIC Montpellier Cancer, one the 8 eight integrated cancer research sites certified by the French National Cancer Institute (INCa). As a national site of reference for oncology, the SIRIC represents an outstanding consortium covering a large field of expertise at the interface of basic, translational and clinical research. Personalized cancer therapy has been identified as a strong priority by the SIRIC.
The position is open for two years, extensible depending on success and funding. Application deadline is 15 January. Interested candidates should send a CV, a letter of motivation and two letters of recommendation to Jacques.colinge@inserm.fr.
