The general focus of the group centers on epigenetic regulation of myogenesis using
facioscapulohumeral muscular dystrophy (FSHD) as paradigm. We are looking for a highly
motivated scientist with a strong interest in transcriptional regulation and epigenetics. The
successful candidate will work in close collaboration with wet biologists and will be in
charge of developing computational and statistical methods to analyze next-generation
sequencing data, including ChIP-Seq and RNA-Seq data.
Computational programming skills (R, Perl, Python or C++) are required.
The laboratory is strategically located within the scientific environment of the San Raffaele
Biomedical Area. There are ample opportunities to interact with other laboratories with
interests in regulation of gene expression and disease. The Division of Regenerative
Medicine has a strong emphasis on development of novel therapeutic approaches for
muscular dystrophy.
Recent publications:
1. Neguembor et al. 2013 FSHD muscular dystrophy region gene 1 binds Suv4-20h1
histone methyltransferase and impairs myogenesis. J Mol Cell Biol 5:294-307
2. Xynos et al. 2013 Overexpression of facioscapulohumeral muscular dystrophy region
gene 1 causes primary defects in myogenic stem cells. J Cell Sci 126:2236-45
3. Pistoni et al. 2013 Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a
mouse model of Facioscapulohumeral muscular dystrophy (FSHD). PLoS Genet
9:e1003186
4. Cabianca et al. 2012 A Long ncRNA Links Copy Number Variation to a
Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy. Cell 149:819-831
Applicants should have demonstrated scientific productivity, good inter-personal and
communication skills, and be able to work independently.
Interested candidates should send curriculum vitae and a list of three individuals that can serve as references by e-mail to:
Davide Gabellini, Ph. D.
Division of Regenerative Medicine
San Raffaele Scientific Institute
Milano, Italy
Phone +39.02.2643.5934
Fax +39.02.2643.5544
E-mail gabellini.davide@hsr.it
Gabellini lab website:
http://www.hsr.it/research/organization/divisions-centers/division-of-regenerative-medicine-stem-cells-and-gene-therapy/davide-gabellini/
