Applicants will either have previously trained in bioinformatics/computer science or hold a PhD in biology-related subjects and have postdoctoral bioinformatics experience. Previous experience of working with next-generation DNA or RNA cancer sequencing data is not required but valuable.

 

Proficiency with at least one scripting language (Python, Perl, etc) and statistical data analysis tools such as R, MATLAB is required. Previous experience of developing computational methods and implementing them in software in a scientific context is also desirable. Expertise in analysis and integration of multiomics data, and statistical interpretation would be a plus.

 

The ideal applicant should have demonstrated the ability to work independently. He/She should have excellent communication skills and be able to articulate clearly the scientific and technical needs, set clear goals and work within an interdisciplinary setting, communicating with wet-lab and computational scientists. 

 

This position requires good verbal and written communication skills in English. 

 

We are looking for a highly motivated individual interested in translational research. The Laboratory of Molecular Genetics studies how mutations in tumor DNA are linked to response or resistance to anti-cancer drugs. Our discoveries (Moroni et al., Lancet Oncology 2005; Misale et al., Nature 2012; Bardelli et al Cancer Discovery 2013; Misale et al., Science Transl Medicine 2014) led to the definition of genetic profiles presently used in the clinic to select colon cancer patients more likely to respond to targeted therapies. Our goal is to define genotype-pharmacological relationship that can translate into far more educated choices for the treatment of patients, leading to greater therapeutic benefit, while at the same time reducing the toxicity of non-effective anticancer therapies. The expected duration of the project is 5 years.

 

The IRCC is a major international centre for research on basic, translational and clinical oncology. For further information consult the website: http://www.ircc.it . The Institute provides an informal environment with easy access to the Alps and local attractions. 

 

 

 

Applications should be sent by e-mail to: simona.destefanis@ircc.it including a CV and contact details for two references. Preliminary enquiries can be addressed to Prof Bardelli (alberto.bardelli@ircc.it)