Research Division: Cancer Studies
First supervisor: Dr Emanuele de Rinaldis
Second supervisor: Professor Anthonius Coolen
Industrial supervisor: Professor Yike Guo, Chief Technical Officer, IDBS
Sponsors: EPSRC/IDBS
Number of studentships: 1
Duration: 3.5 years
Study mode: Full time
Eligibility: Home fees and stipend and EU fees only
Start date: 01 October 2011
Closing date for applications: 15 August 2011
Reference: 11/DCS/S-01
First supervisor: Dr Emanuele de Rinaldis
Second supervisor: Professor Anthonius Coolen
Industrial supervisor: Professor Yike Guo, Chief Technical Officer, IDBS
Sponsors: EPSRC/IDBS
Number of studentships: 1
Duration: 3.5 years
Study mode: Full time
Eligibility: Home fees and stipend and EU fees only
Start date: 01 October 2011
Closing date for applications: 15 August 2011
Reference: 11/DCS/S-01
Project title
Development of novel mathematical approaches for the integrative analysis of Next Generation Sequencing (NGS) data and application to breast cancer studies
Project description
Modern genomics provide the ability to identify DNA mutations, copy number aberrations and somatic rearrangements in cancer genomes at an unprecedented pace and resolution. This information, accrued by Next-Generation-Sequencing (NGS) and array based technologies, can be used to establish associations between the "molecular picture" of a tumor and its pathological and clinical features.
The study we propose focuses on the development of novel algorithms for the integrative analysis of genomics data, clinical and pathological tumor information. These algorithms will employ systematic Bayesian protocols for handling the inevitable mismatch between number of patients and the dimensionality of the genomics data, by allowing explicitly for cohort heterogeneity and by incorporating so-called sparsety priors that use bioinformatic (e.g. gene regulation) information wherever possible.
The ideal candidate will have a background in applied Mathematics accompanied by a strong interest in genomics and cancer biology. Good programming skills are also required, preferentially in R and/or MatLab.
The study we propose focuses on the development of novel algorithms for the integrative analysis of genomics data, clinical and pathological tumor information. These algorithms will employ systematic Bayesian protocols for handling the inevitable mismatch between number of patients and the dimensionality of the genomics data, by allowing explicitly for cohort heterogeneity and by incorporating so-called sparsety priors that use bioinformatic (e.g. gene regulation) information wherever possible.
The ideal candidate will have a background in applied Mathematics accompanied by a strong interest in genomics and cancer biology. Good programming skills are also required, preferentially in R and/or MatLab.
Application details
This studentship covers home students (fees and stipend) and EU students (fees only).
For a full award students must have a relevant connection with UK (usually established by residence). If a student fulfils the academic requirement but has a relevant connection with an EU country other than the UK they may be eligible for an award of fees only (i.e. no maintenance grant to the student).
Please apply by CV and personal statement to Dr Emanuele de Rinaldis.
Although the application deadline is 15 August 2011 please apply as soon as possible as the studentship may become unavailable should a suitable candidate be selected prior to the closing date.
For a full award students must have a relevant connection with UK (usually established by residence). If a student fulfils the academic requirement but has a relevant connection with an EU country other than the UK they may be eligible for an award of fees only (i.e. no maintenance grant to the student).
Please apply by CV and personal statement to Dr Emanuele de Rinaldis.
Although the application deadline is 15 August 2011 please apply as soon as possible as the studentship may become unavailable should a suitable candidate be selected prior to the closing date.
Contacts
For scientific enquiries about the project: Emanuele De Rinaldis.
For administrative/general application enquiries: Rebecca Trumble.
For administrative/general application enquiries: Rebecca Trumble.
