Senior Bioinformatician/Technologist - 3D chromatin architecture and non-coding RNAs @IIT
A fully supported senior bioinformatician position is immediately available at the Italian Institute of Technology in Genova. The successful candidate will work in a multi-disciplinary team and will analyze in-house produced multi-omic data aiming to understand the role of non-coding RNAs in mediating 3D chromatin architecture in embryonic stem cells and cancer stem cell models.
The “3D Chromatin Conformation and RNA Genomics” Research Unit is coordinated by Dr. Dafne Campigli Di Giammartino and aims at understanding how non-coding elements (DNA/RNA) and their epigenetic/epitranscriptomic modifications regulate 3D genome architecture and gene expression. To address this question, we use cutting-edge chromatin conformation assays (e.g.Hi-C, Hi-ChIP etc) in conjunction with other -omics techniques (e.g. ChIPseq, RNA-seq etc.) and in combination with CRISPR-based genetic and epigenetic engineering tools in mouse stem cells as well as in human tumor stem cells.
Moreover, as a member of the FANTOM6 consortium, bioinformaticians in our lab have the opportunity to attend and actively participate to this international consortium with ample opportunities for collaborations within the IIT and with extramural institutions to implement new workflows and pipelines
Main responsibilities
- Analyzing in-house produced NGS data (ChIP-seq, RNA-seq, Hi-C, HiChIP,Micro-C, RADICL-seq etc.) and integrating with publicly available datasets
- Engaging with our bioinformatic collaborators to optimize analysis workflows and share expertise
- Supporting experimental biologists by integrating multi-omic analyses to identify optimal targets for functional validation
- Interpreting results of the analyzed datasets to create figures for grant proposals (e.g. Horizon EU funds, AIRC etc), for internal as well as external oral presentations, and publications in peer-reviewed journals
Essential requirements
- PhD in Bioinformatics/Computational Biology/Computer Science or 5 years hands-on experience in analysis of NGS datasets
- High proficiency level in programming using R and/or Python
- A solid understanding of statistical methodologies commonly applied to biological data analysis
- Proven ability to analyse next-generation sequencing data such as RNA-seq, ChIPseq etc
- Ability to work and think independently, and collaboratively in a highly interdisciplinary environment, with a pro-active attitude
- Good publication record
- Good command of spoken and written English
Please submit your application including a detailed CV, contact details of at least 2 references and a cover letter outlining motivation, experience and qualifications using the online form https://app.ncoreplat.com/jobposition/679633/technologist-position-as-senior-bioinformatician-3d-chromatin-and-non-coding-rnas-id-25000012-it/istituto-italiano-di-tecnologia
Referent: Dr Dafne Campigli Di Giammartino
Location: Genova, Italy
Application deadline: October 30th 2025
Contact email for further details: dafne.campigli@iit.it
