We are looking for a motivated Post-doctoral computational biologist with background in epigenetics and/or immunology, to investigate key epigenetic mechanisms involved in the protection and in the regeneration of hematopoietic stem cells upon damage.Join our team at the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC)!
Your future workplace:
The group led by Dr. Manlio Vinciguerra, PhD, within the Center of Translational Medicine (CTM), at FNUSA-ICRC. Dr. Vinciguerra authored more than 110 papers and he joined ICRC after having held positions at the University of Geneva, the European Molecular Biology Laboratory (EMBL) and the University College London (UCL).
You will:
* analyze large scale transcriptomic and epigenomic data from various sources (animal, human, cells and tissues) generated in the lab or retrieved from public databases (analysis and functional interprettion of NGS data)
* use various software packages, open sources and commercial one
* be able to graphically represent omic data in visually appealing fashion
* interact with scientists specialized in diverse topics of bio-medicine, including cancer and immunity
Benefits
* Truly international work environment
* Participation in international medical research
* contribution to addressing the major health issues of today
* Professional support for your grant applications
* Short-term and long-term internships abroad
* Close cooperation with wide range of stake-holders from top researchers and clinicians to opinion leaders in pharmaceutical/biotechnological industry
* Mentorship, Competitive salary,
* 5 weeks of vacation
Selection process
The candidates are invited to send their CV and motivation letter to kristina.chuda@fnusa.cz
We are looking forward to hearing from you.
Your CV will be carefully reviewed, only short-listed candidates will be contacted by 10 Feb 2017 (at the latest) with more details regarding the next round of interviews.
Disclaimer:
We are pleased to consider all qualified applicants for employment without regard to age, gender, marital status, sexual orientation, race, color, religion, ethnicity, disability, national origin, nationality, political opinion or any other aspect unrelated to work.
By responding to this invitation and/or sending your CV and any other personal materials to St. Anne's University Hospital, you consent to the collection, processing and storage of your personal data in accordance with Act No. 101/2000 Coll., the protection of personal data. You are providing St. Anne's University Hospital with these data solely for the purpose of mediating employment, the period however being no longer than one year from submitting. Should you not reclaim the materials submitted by you, they will be discarded after the period has expired.
Additional comments
The laboratory is broadly interested in the epigenetics of nutrition and cancer. Current projects include:
* Study of epigenetic pathways involving macroH2A1, a variant of histone H2A, a repressor of gene transcription in the differentiation of liver cancer stem cells.
* Study of macroH2A1 in the differentiation of hematopoietic stem cells.
* Study of the interplay between diet, immune system and gut microbiota during aging. To achieve these goals we use various in vitro and in vivo models and we generated/will generate a large quantity of next generation sequencing data (RNA-Seq, ChIP-Seq, metagenomics, microarrays), which are fundamental to understand mechanisms and identify druggable targets.
Key References:
* Sheedfar F, Vermeer M, Pazienza V, Villarroya J, Rappa F, Cappello F, Mazzoccoli G, Villarroya F, van der Molen H, Hofker MH, Koonen DP, Vinciguerra M. (2015) Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high- fat diet. Int J Obes (Lond). 39(2):331-8.
* Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, Peyrou M, Marino A, Scibetta N, Williams R, Mazzoccoli G, Federici M, Pazienza V, Vinciguerra M. (2013) Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PLoS One. 8(1):e54458.
* Borghesan, M, Fusilli, C, Rappa, F, Panebianco, C, Rizzo, G, Oben, JA, Mazzoccoli, G, Faulkes, C, Pata, I, Agodi, A, Rezaee, F, Minogue, S, Warren, A, Peterson, A, Sedivy, JM, Douet, J, Buschbeck, M, Cappello, F, Mazza, T, Pazienza, V, Vinciguerra, M (2016) DNA hypomethylation and histone variant macroH2A1 synergistically attenuate chemotherapy-induced senescence to promote hepatocellular carcinoma progression. Cancer Res 76(3):594-606.
* Pazienza V, Panebianco C, Rappa F, Memoli D, Borghesan M, Cannito S, Oji A, Mazza G, Tamburrino D, Fusai G, Barone R, Bolasco G, Villarroya F, Villarroya J, Hatsuzawa K, Cappello F, Tarallo R, Nakanishi T, Vinciguerra M (2016) Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis. Epigenetics Chromatin. 25;9:45.
Offer Requirements
REQUIRED EDUCATION LEVEL
Biological sciences: PhD or equivalent
Computer science: PhD or equivalent
REQUIRED LANGUAGES
ENGLISH: Excellent
Skills/Qualifications
PhD in relevant discipline, such as Bioinformatics, Biostatistics, Structural Biology/Epigenetics
Basic knowledge of physiology and pathology, and curiosity to learn.
expertise in handling big data (RNA-Seq, ChIP-Seq, metagenomics etc)
Knowledge of at least one among R, python, perl
Expertise in data retrieval from public sources
Experience in using open-source bioinformatic software (https://en.wikipedia.org/wiki/List_of_open-source_bioinformatics_software), as well as commercial ones (PARTEK, Ingenuity Pathway Analysis and others)
A proven record of publication in reputable scientific journals
The correct cultural background (training in Computational Biology / Computer Science / Statistics or a mix of the three) and a strong interest in working with high throughput data will be considered at the same level of specific experience in the above-mentioned fields.
Specific Requirements
* A team oriented person with a good knowledge of English, detail oriented and meticulous
* An excellent communicator, with a strong desire for career development
* Available to occasionally travel in other European for training and collaborative experimental efforts within the project
Work location
1 offer(s) available at
St. Anne University Hospital Brno
Czech Republic
Brno
Studentská, Brno (Biopark)
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