Job Description:
The research group of prof. Gianluigi Condorelli at National Research Council - University of Milano Bicocca is looking for one or more bioinformatician(s) with specific experience and/or interest in High Throughput data analysis.
The candidate(s) will be mainly in charge of the analysis of Next-Generation sequencing genome and transcriptome datasets for a range of applications and projects in the experimental labs (transcriptomics; mutation detection; ChiP Seq etc), but analyses of other datasets (such as microarray) will be part of the duties.
The scientific focus of the group is on molecular medicine applied to cardiovascular diseases and a rich range of approaches is currently conducted in the experimental labs (1-4).
The correct cultural background (training in Biology / Computer Science / Statistics or a mix of the three) and a strong interest in working in HT data analysis will be considered at the same level of specific experience in the above-mentioned fields.
Good knowledge of Scientific English will be positively evaluated for this position, together with good presentation and teamwork skills.
The salary and type of contract will be commensurated to the candidate\'s skills and professional profile.
A CV with one professional reference, details on educational background and of the biological and/or bioinformatic and/or data analysis skills and experience should be sent by email for a preliminary selection to
Alessandro Guffanti, Bioinformatics, Genomnia:
alessandro.guffanti@genomnia.com
Please note that this position is NOT associated with Genomnia, which helps only with the candidate preliminary selection
including the following sentence for privacy at the end of the CV:
“Autorizzo il trattamento dei dati personali contenuti nel mio curriculum vitae in base art. 13 del D. Lgs. 196/2003
References
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Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Ruiz-Lozano, P., Gallo, P., Segnalini, P., Bang, M.L., Dorn, G.W.2nd, Ellingsen, O., Croce, C.M., Peschle, C., and Condorelli, G.(2007): MicroRNA-133 controls cardiac myocyte hypertrophy. Nature Medicine, 13(5):613-8.
Elia, L., Contu, R., Quitavalle, M., Varrone, F., Chimenti, C., Russo, M.A., Cimino, V., De Marinis, L.,, Frustaci, A., Catalucci, D., Condorelli, G.(2009): Reciprocal regulation of microRNA-1 and IGF-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions; Circulation, 120(23):2377-85.
Quintavalle, M., Elia, L., Condorelli, G.* and Courtenidge, S.* (2010), MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J. Cell Biol., 189(1):13-22
Zhang, D.H., Latronico, M.V.G., Zhang, J.L., Contu, R., Rizzi, R., Catalucci, D., Peterson, K.L., Brown, J.H., Chen, J, Sonenberg, N. and Condorelli G. (2010): mTORC-1 regulates cardiac function and myocyte survival through 4E-BP-1 inhibition. The Journal of Clinical Investigation, 120(8):2805-16
job offers
Location: EBI - Hinxton, near Cambridge, UK
Staff Category: Staff Member
Contract Duration: 3 years
Grading: 5
Closing Date: 26 June 2011
Reference number: EBI_00089
Staff Category: Staff Member
Contract Duration: 3 years
Grading: 5
Closing Date: 26 June 2011
Reference number: EBI_00089
Job Description: Presso il laboratorio di Bioinformatica dell IRCCS E.Medea.
Ambito scientifico: analisi della diversità genetica nelle poplazioni umane; identificazione di regioni genomiche sottoposte a selezione naturale; associazione genotipo/fenotipo per tratti complessi; analisi di network di interazione molecolare;
Requistiti: Laurea Magistrale in Fisica/Bioingegneria/Informatica; esperienze di programmazione in linguaggi quali R, C++; conoscenza di database relazionali (MySQL).
Job Description: The Institute of Experimental Neurology (INSPE) and Center for Translational Genomics and BioInformatics at San Raffaele Scientific Institute are seeking an outstanding candidate who will work across the Institute and the Center to work on new and challenging aspects of the genetics of neurological disease. The focus will be on the analysis of GWAS data as well as the integration of whole genome and exome re-sequencing data. The candidate will be expected to analyze SNP, INDEL and CNV data, perform genetic imputation across internal and public datasets, adjust for genetic stratification and correlation with clinical phenotypes.
By being affiliated to both INSPE and the Center for Translational Genomics and Bioinformatics, the candidate will benefit from being immersed in a wider bioinformatics and genomics environment as well as the clinical/biological environment of relevance to the project. GWAS and fine-mapping data from International Consortia projects (IMSGC and Immunochip), studies on pharmacogenomics of MS and AD patients and related clinical information are already available.
Essential Requirements:
-PhD or equivalent experience in Biology, Genetics, Bioinformatics, Computational Biology, Statistics or Applied Mathematics
- Good understanding of genetics and molecular biology
- Documented experience with statistical programs used for analyses of GWAS data such as EIGENSTRAT, PLINK, SAS, SPSS and imputation, such as MACH.
- Knowledge of statistical packages such as R, Bioconductor
- Experience in at least one scripting language, e.g. Perl, Python
- Good knowledge of written and spoken english
Desirable Requirements:
- Experience with analysis exome and whole genome re-sequencing data, e.g. alignment, variant calling and variant annotation
- Experience with genomic data mining and integration and pathway analysis, such as GSEA, Ingenuity
- Knowledge of programming languages such as Java, Perl, C
- Experience with database management and database design, e.g MySQL, PostgreSQL
- Web development and management experience
- Relevant publication record
Conditions:
Salary: According to experience and profile
Duration: 2-3 years
Start date: as soon as possible
How to apply:
Please send your application to stupka.elia@hsr.it and martinelli.filippo@hsr.it
Please include:
- cover letter
- CV including contact details
- names of two referees (with email and phone number)
Job Description:
The Center will be involved in a significant number of cutting-edge projects of translational nature and clinical relevance and international collaborations. We are therefore looking for passionate and bright candidates from a variety of disciplines (biology, maths, statistics, computer science, physics), who must share an interdisciplinary mindset and a passion to build and develop the Center into a world-class entity.
We are seeking to hire approximately 10-12 people within the coming months covering the following areas:
* Scientists who enjoy working on the interface between the wet lab and the dry lab, who are capable to design, perform and analyze their own experiments
* Bioinformaticians involved in the analysis of next-generation sequencing data
* Biostatisticians involved in staistical genetics, transcriptomic signatures, epigenetic profiling
* Mathematcians/Statisticians involved in building integrated models and networks from next-gen sequencing data
* Computational biologists interested in integrating genomics and high throughput imaging approaches, as well as computational scientists interested in developing novel data visualization methods
* Several post-doctoral positions will be available on specific research projects already funded, which apply genomics in disease areas such as Allergy, Multiple Sclerosis, Alzheimer’s, Parkinson’s.
-a cover letter explaining the role they would like to undertake within the Center, even if it is not listed in this job ad, stating clearly why they would be a good fit to the proposed role, and what they would bring to the Center in terms of expertise, ideas, talent.
-a CV including a list of publications
-List of referees
Please send all the material to Elia Stupka (stupka.elia@hsr.it), Co-Director of the Center For Translational Genomics and Bioinformatics
Applications are open and ongoing during 2011 until all roles will be filled.
The San Raffaele Scientific Institute in Milan, Italy, has recently launched its new Center for Translational Genomics and Bioinformatics and is seeking talented scientists in several roles.
The Center will be involved in a significant number of cutting-edge projects of translational nature and clinical relevance and international collaborations. We are therefore looking for passionate and bright candidates from a variety of disciplines (biology, maths, statistics, computer science, physics), who must share an interdisciplinary mindset and a passion to build and develop the Center into a world-class entity.
We are seeking to hire approximately 10-12 people within the coming months covering the following areas:
* Scientists who enjoy working on the interface between the wet lab and the dry lab, who are capable to design, perform and analyze their own experiments
* Bioinformaticians involved in the analysis of next-generation sequencing data
* Biostatisticians involved in staistical genetics, transcriptomic signatures, epigenetic profiling
* Mathematcians/Statisticians involved in building integrated models and networks from next-gen sequencing data
* Computational biologists interested in integrating genomics and high throughput imaging approaches, as well as computational scientists interested in developing novel data visualization methods
* Several post-doctoral positions will be available on specific research projects already funded, which apply genomics in disease areas such as Allergy, Multiple Sclerosis, Alzheimer’s, Parkinson’s.
Context
The San Raffaele Institute is part of the largest biomedical park in Italy and it has integrated clinics (as part of the San Raffaele Hospital with over 1,300 beds), research and education for the last 20 years. In 1992 San Raffaele expanded with the inauguration of DIBIT, a building dedicated to basic science, with a research space of about 12,000 square meters where at present 250 people are employed in basic, translational and clinical research, including scientists, technicians and administrative personnel, along with additional 300 fellows, consultants, trainees and graduate students. In the last 2 years the campus has undergone a further expansion by developing the DIBIT-2, which has expanded almost three-fold the floor space devoted to research and substantially increased and empowered research in the different fields where San Raffaele has become highly renowned. As part of this expansion, and in recognition of the pivotal role that –omics is increasingly playing in translational research, the Center For Translational Genomics and Bioinformatics was launched last year. The Center is equipped with state of the art genomics technology (Illumina Hi-Seq, microarray platforms, etc) as well as a dedicated high performance computing facility with over 1,000 cores, all connected via Infiniband, including several nodes with 1TB of memory.Remuneration/Applications
We will offer competitive salaries commensurate with experience and role. Candidates should send:-a cover letter explaining the role they would like to undertake within the Center, even if it is not listed in this job ad, stating clearly why they would be a good fit to the proposed role, and what they would bring to the Center in terms of expertise, ideas, talent.
-a CV including a list of publications
-List of referees
Please send all the material to Elia Stupka (stupka.elia@hsr.it), Co-Director of the Center For Translational Genomics and Bioinformatics
Applications are open and ongoing during 2011 until all roles will be filled.
