Carmelo Laudanna
Socio Associato
Ricercatore
IRB Barcelona: Institute for Research in Biomedicine
Contact Information
RESEARCH AREA
algorithms,biological data integration,biological ontologies,comparative genomics,network systems,sequence analysis,system biology
RESEARCH ACTIVITY
I'm a Ph.D. Bioinformatics scientist with a biological background. My current activities focus on processing and exploring NGS (Next Generation Sequencing) data to use bioinformatics resources for data analysis and interpretation.
My area of expertise includes the use of different programming languages to implement, adapt and/or optimize methods and standard algorithms for data analysis.
During my PhD the research activity was held at the Bioinformatics CORE Lab at the Genetic Research Institute ”Gaetano Salvatore” (IRGS/BioGeM), and at the Molecular Biology Lab at the Department of Sciences and Technologies, University of Sannio, Italy.
Work, carried on, was relative to Bioinformatics, Computational Biology and Systems Biology. Specifically I worked on Gene Expression Analysis from microarray and RNA-seq data and analysis of miRNA expression projects; Discovery of Transcription Factors Binding Sites, Gene Signature and Survival Analysis methods, resulting in the development of basic knowledge to be able to perform a preliminary analysis starting from the raw data, and the ability to apply different methods of analysis of data from different platforms (Affymetrix; Illumina; Life Technologies; etc.) and according to the nature of the experimental design (Time Course, Steady State, etc.).
My efforts have produced publications in International Journals and development of R/CRAN packages.
I spent five years as Bioinformatics PostDoc at the Laboratory of Molecular Oncology Dpt. of Experimental and Clinical Medicine Magna Græcia University of Catanzaro, where my focus was to analyze and manipulate Next Generation Sequencing (NGS) data, and to develope reliable methods to assess different NGS approaches.
My area of expertise includes the use of different programming languages to implement, adapt and/or optimize methods and standard algorithms for data analysis.
During my PhD the research activity was held at the Bioinformatics CORE Lab at the Genetic Research Institute ”Gaetano Salvatore” (IRGS/BioGeM), and at the Molecular Biology Lab at the Department of Sciences and Technologies, University of Sannio, Italy.
Work, carried on, was relative to Bioinformatics, Computational Biology and Systems Biology. Specifically I worked on Gene Expression Analysis from microarray and RNA-seq data and analysis of miRNA expression projects; Discovery of Transcription Factors Binding Sites, Gene Signature and Survival Analysis methods, resulting in the development of basic knowledge to be able to perform a preliminary analysis starting from the raw data, and the ability to apply different methods of analysis of data from different platforms (Affymetrix; Illumina; Life Technologies; etc.) and according to the nature of the experimental design (Time Course, Steady State, etc.).
My efforts have produced publications in International Journals and development of R/CRAN packages.
I spent five years as Bioinformatics PostDoc at the Laboratory of Molecular Oncology Dpt. of Experimental and Clinical Medicine Magna Græcia University of Catanzaro, where my focus was to analyze and manipulate Next Generation Sequencing (NGS) data, and to develope reliable methods to assess different NGS approaches.
SELECTED PUBLICATIONS
[1] D. M.Oliveira*, C. Laudanna*, M. Migliozzi, , P. Zoppoli, G. Santamaria, K. Grillone, L. Elia, C. Mignogna, F. Biamonte, R. Sacco, F. Corcione, G. Viglietto, D. Malanga, and A. Rizzuto, “Identification of different mutational profiles in cancers arising in specific colon segments by Next Generation Sequencing.,” Oncotarget (accepted), 2018.
[2] D. M.Oliveira, G. Santamaria, C. Laudanna, M. Migliozzi, , P. Zoppoli, M. Quist, C. Grasso, C. Mignogna, L. Elia, M. Faniello, C. Marinaro, R. Sacco, F. Corcione, G. Viglietto, D. Malanga, and A. Rizzuto, “Identification of Copy Number Alterations in colon cancer from analysis of amplicon-based Next generation sequencing data.,” On- cotarget (accepted), 2018.
[3] A. Remo, E. Manfrin, P. Parcesepe, A. Ferrarini, H. Hye-Seung, M. Ugnius, C. Laudanna, M. Simbolo, D. Malanga, D. M.Oliveira, E. Baritono, T. Colangelo, L. Sabatino, J. Giuliani, E. Molinari, M. Garonzi, L. Xumerle, G. Giordano, M. Delledonne, C. Ghimenton, F. Lonardo, F. D’angelo, F. Grillo, L. Mastracci, G. Viglietto, M. Ceccarelli, V. Colan- tuoni, A. Scarpa, and M. Pancione, “Centrosome Linker-induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers.,” Molecular Cancer Research (accepted), 2018.
[4] C. De Marco, C. Laudanna, N. Rinaldo, D. M.Oliveira, C. De Marco, M. Scrima, M. Ravo, A. Weisz, M. Ceccarelli, E. Caira, A. Rizzuto, P. Zoppoli, D. Malanga, and G. Viglietto, “Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.,” PlosOne, 2017.
[5] C. Votino*, C. Laudanna*, P. Parcesepe, G. Giordano, A. Remo, E. Manfrin, and M. Pancione, “Aberrant BLM cy- toplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer,” Journal of Gastroenterology, pp. 1–14, 2016.
[6] S. M. Pagnotta*, C. Laudanna*, M. Pancione, L. Sabatino, C. Votino, A. Remo, L. Cerulo, P. Zoppoli, E. Manfrin, V. Colantuoni, and M. Ceccarelli, “Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARg and TNFa Signaling,” PLoS ONE, vol. 8, 2013.
[2] D. M.Oliveira, G. Santamaria, C. Laudanna, M. Migliozzi, , P. Zoppoli, M. Quist, C. Grasso, C. Mignogna, L. Elia, M. Faniello, C. Marinaro, R. Sacco, F. Corcione, G. Viglietto, D. Malanga, and A. Rizzuto, “Identification of Copy Number Alterations in colon cancer from analysis of amplicon-based Next generation sequencing data.,” On- cotarget (accepted), 2018.
[3] A. Remo, E. Manfrin, P. Parcesepe, A. Ferrarini, H. Hye-Seung, M. Ugnius, C. Laudanna, M. Simbolo, D. Malanga, D. M.Oliveira, E. Baritono, T. Colangelo, L. Sabatino, J. Giuliani, E. Molinari, M. Garonzi, L. Xumerle, G. Giordano, M. Delledonne, C. Ghimenton, F. Lonardo, F. D’angelo, F. Grillo, L. Mastracci, G. Viglietto, M. Ceccarelli, V. Colan- tuoni, A. Scarpa, and M. Pancione, “Centrosome Linker-induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers.,” Molecular Cancer Research (accepted), 2018.
[4] C. De Marco, C. Laudanna, N. Rinaldo, D. M.Oliveira, C. De Marco, M. Scrima, M. Ravo, A. Weisz, M. Ceccarelli, E. Caira, A. Rizzuto, P. Zoppoli, D. Malanga, and G. Viglietto, “Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.,” PlosOne, 2017.
[5] C. Votino*, C. Laudanna*, P. Parcesepe, G. Giordano, A. Remo, E. Manfrin, and M. Pancione, “Aberrant BLM cy- toplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer,” Journal of Gastroenterology, pp. 1–14, 2016.
[6] S. M. Pagnotta*, C. Laudanna*, M. Pancione, L. Sabatino, C. Votino, A. Remo, L. Cerulo, P. Zoppoli, E. Manfrin, V. Colantuoni, and M. Ceccarelli, “Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARg and TNFa Signaling,” PLoS ONE, vol. 8, 2013.
EDITORIAL BOARDS
Review Editor on the Editorial Board of Cancer Genetics (specialty section of Frontiers in Genetics and Frontiers in Oncology)
MAIN TEACHINGS
- University "Magna Graecia" of Catanzaro: Insegnamento di Patologia Generale MED/04 nel C.I. di Fisiopatologia Clinica Anno II, Semestre I (CFU 3), istituito presso il Corso di Laurea in INGEGNERIA INFORMATICA E BIOMEDICA L8, afferente al settore scientifico-disciplinare MED/04.
- University "Magna Graecia" of Catanzaro (June 2014 - July 2014): Course for the tudents of the PhD programme in Molecular and translational oncology, entitled “Introduction to Bioinformatics”.
- University "Magna Graecia" of Catanzaro (June 2014 - July 2014): Course for the tudents of the PhD programme in Molecular and translational oncology, entitled “Introduction to Bioinformatics”.
