Positions available for Bioinformaticians at the IRC@C, Candiolo, Turin, Italy

The IRC@C is a major international centre for research on basic, translational and clinical oncology. For further information consult the website: http://www.ircc.it . The Institute provides an informal environment with easy access to the Alps and local attractions.

Applications are invited for Bioinformaticians to support multidisciplinary research in a number of research projects.

Proficiency with scripting languages (Python, Perl, etc) and statistical data analysis tools such as R, MATLAB is required. Previous experience of developing computational methods and implementing them in software in a scientific context is also desirable. Expertise in analysis and integration of multiomics data, and statistical interpretation would be a plus.

The ideal applicants should have demonstrated the ability to work independently. They should have excellent communication skills and be able to articulate clearly the scientific and technical needs, set clear goals and work within an interdisciplinary setting, communicating with wet-lab and computational partners.

Salary will be commensurate to experience.

Applications should be sent by e-mail to: simona.destefanis@ircc.it including a CV and contact details for two references.

Preliminary enquiries can be addressed to Dr Bardelli (alberto.bardelli@ircc.it) or Dr Medico (enzo.medico@ircc.it).

Closing date: May 1st 2013. Candidates will be reviewed on a rolling base, so early application is advised.

POST 1: TWO RESEARCH ASSOCIATES IN BIOINFORMATICS - LABORATORY OF MOLECULAR GENETICS

The Laboratory of Molecular Genetics studies how mutations in tumor DNA are linked to response or resistance to anti-cancer drugs. Our discoveries (Moroni et al., Lancet Oncology 2005, Di Nicolantonio et al., JCO 2008, Misale et al., Nature 2012) led to the definition of genetic profiles presently used in the clinic to select colon cancer patients more likely to respond to targeted therapies. Our goal is to define genotype-pharmacological relationship that can translate into far more educated choices for the treatment of patients, leading to greater therapeutic benefit, while at the same time reducing the toxicity of non-effective anticancer therapies.

Applicants will either have or be in the process of submitting a PhD in bioinformatics or hold a PhD in a molecular biology-related subject and have postdoctoral bioinformatics experience. Previous experience of working with next-generation DNA or RNA cancer sequencing data is also essential.

POST 2: RESEARCH ASSISTANT IN BIOINFORMATICS - LABORATORY OF ONCOGENOMICS

The Laboratory of Oncogenomics currently aims at the following integrated goals: (i) Genomic profiling of colorectal and other neoplastic tissues to find molecular signatures associated to metastatic progression, mutational status and response to treatment. (ii) Systematic search for genes modulating cancer cell invasive/metastatic ability and responsiveness to targeted therapy; (iii) Exploitation of these genes as additional therapeutic targets, or as diagnostic indicators; (iv) definition of molecular signatures in cell-based models of cancer progression and treatment resistance, and subsequent validation of their clinical value.

Applicants at both the postgraduate and postdoctoral level will be considered, provided that they have previous bioinformatics experience. In particular, experience with microarray data analysis is highly desired. The ability to analyze next-generation DNA or RNA cancer sequencing data would also be a plus.