BITS2018-SINGLE-CELL REVOLUTION
Opportunities and challenges in Single-Cell Biology

The cell is the basic unit of life, but only very recent technological advancements that span from single cell RNA-sequencing to live imaging, allowed scientists to actually observe and measure the behaviour of biological processes at the level of individual cell. These new technologies revealed that no two cells are exactly the same and subtle changes that make each one unique are emerging.

The increase in resolution is shaking our perspective on very basic biological processes and is revealing new cellular phenomena. This scientific revolution can pave the way for a novel interpretation of biological processes, especially those at the basis of complex phenotypes.

This free workshop focuses on the opportunities and challenges that the "single-cell revolution" brings at the biotechnological and data-analysis level, but also on the identification of new problems and paradigms in modern biology. Condensed in one day, we will see examples of the biological insights that can be gained while moving from “many “to “one”.

Topics: Single Cell Sequencing, ImmunologyEpigenetics, Evolution, Bioinformatics 

Organizers: Matteo Cereda, Matteo Osella, Valentina Proserpio, Michele Caselle

The workshop is free, for any question send an email to one of the following addresses:

- matteo.cereda@iigm.it

- mosella@to.infn.it

- caselle@to.infn.it

 

CONFIRMED SPEAKERS

  • Dr Antonio ScialdoneHelmholtz Zentrum München, Institute of Epigenetics and Stem Cells, München, DE
  • Dr Luigia PaceImmune Regulation Lab, Italian Institute of Genomic Medicine (IIGM), Torino, IT
  • Dr Davide Cittaro, Center for Translational Genomics and Bioinformatics, San Raffaele Hospital, Milan, IT
  • Dr Davide Cacchiarelli, Genomic Medicine, Telethon Institute of Genomics and Medicine, Naples, IT
  • Dr Giacomo Donati, Stem Cell Biology and Cell Plasticity Laboratory, University of Torino, Torino, IT
  • Dr Valentina Proserpio, Epigenetics Lab, Italian Institute of Genomic Medicine (IIGM), Torino, IT
  • Dr Gennaro Gambardella, Genomic Medicine, Telethon Institute of Genomics and Medicine, Naples, IT
  • Dr Valeria Ranzani, Integrative Biology, INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, IT
  • Dr Saveria Mazzara, Integrative Biology, INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, IT
  • Luca Alessandrì, Dept. of Molecular Biotechnology and Health Sciences, University of Torino, Torino, IT 
  • Dr Marco Antoniotti, Department of Informatics, Systems and Communication (DISCO), University of Milan Bicocca, Milan, IT
  • Dr Natalia Kunowska, Immune Genomics, Cellular Genetics Programme, The Wellcome Trust Sanger Institute, Hinxton, UK

 

ORAL COMMUNICATION & POSTER SUBMISSION

Deadline: June 1st
All attendees are eligible to submit posters when registering to attend. All abstracts must be submitted using the conference submission site by the abstract deadline: June 1st. You will be notified by Friday 8th June if your communication has been accepted.

 

DATE & VENUE

When: June 26th from 9:00 to 19:00

Where: Aula Darwin @ Molecular Biotechnology Center, Via Nizza 52, 10126 Torino, IT

 

PROGRAM 

9:00 9:20 Registration    
First Session
9:30 10:20 Davide Cittaro, Translational Genomics and Bioinformatics, San Raffaele Hospital
     Analysis of single cell data: do's and don’ts
10:30 11:00 Saveria Mazzara, INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi" Milan, IT
     Bioinformatic workflow assessment of different single-cell RNAseq platforms
 
11:00 11:20 Coffee break    
 
11:30 12:20 Antonio Scialdone, Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München
    Investigating cellular fate decision with single-cell RNA-sequencing
12:30 13:00 Luca Alessandrì, Dept. of Molecular Biotechnology and Health Sciences, University of Torino
    CASC: Classification Analysis of Single Cell Sequencing Data
 
13:00 13:50 Lunch break    
 
Second Session
14:00 14:50 Luigia Pace, Immune Regulation Laboratory, Italian Institute for Genomic Medicine (IIGM)
     Linking heterochromatin architecture and CD8+ T cell fate commitment
15:00 15:30 Valeria Ranzani, INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi" Milan, IT
     Single Cell Transcriptome Analysis of Human Tumor-Infiltrating CD4+ T cells 
15:30 16:00 Marco Antoniotti, Department of Informatics, Systems and Communication (DISCO), University of Milan Bicocca Milan, IT
     Reconstructing Mutational Graphs of Tumor Evolution from Single Cells Data
16:00 16:30 Natalia Kunowska, Immune Genomics, Cellular Genetics Programme, The Wellcome Trust Sanger Institute, Hinxton, UK
     Evolutionary architecture of innate immune response
 
16:30 16:50 Poster Session   
 
16:50 17:40 Davide Cacchiarelli, Genomic Medicine, Telethon Institute of Genomics and Medicine
    Dissecting cell fate decisions through single-cell transcriptomics
17:50 18:20 Giacomo Donati, Stem Cell Biology and Cell Plasticity Laboratory, University of Torino
    Understanding Wnt-mediated crosstalk between epidermal stem cells
18:30 19:00 Gennaro Gambardella, Genomic Medicine, Telethon Institute of Genomics and Medicine
    Inferences of pathway activity from single-cell transcriptomics to reveal biomarkers and mechanisms of drug sensitivity in breast cell-lines 
 
19:00 TBD Social Drinks   
 
 

CONTACTS

For any further information drop an email to any of these addressess:

  • matteo.cereda@iigm.it
  • mosella@to.infn.it
  • caselle@to.infn.it
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